Electroencephalographic and Convulsive Effects of Binge Doses of (+)- Methamphetamine, 5-methoxydiisopropyltryptamine, and (±)-3,4- Methylenedioxymethamphetamine in Rats
| Autor: | Katherine D. Holland, Nicole R. Herring, Charles V. Vorhees, Michael T. Williams, Tori L. Schaefer, Devon L. Graham |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Tachycardia 0303 health sciences medicine.diagnostic_test Ecstasy MDMA Methamphetamine Electroencephalography Article 3. Good health 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Monoamine neurotransmitter Neurochemical medicine Pharmacology (medical) medicine.symptom Psychology Myoclonus 030217 neurology & neurosurgery 030304 developmental biology medicine.drug |
| Zdroj: | The Open Neuropsychopharmacology Journal. 5:1-8 |
| ISSN: | 1876-5238 |
| Popis: | The abuse of drugs such as methamphetamine (MA), 3,4-methylenedioxymethamphetamine (Ecstasy, MDMA), and 5-methoxydiisopropyltryptamine (5-MeO-DIPT; Foxy) is global. Symptoms from taking these drugs include tachycardia, agitation, hyperpyrexia, and sometimes seizures. We compared the EEG effects of these drugs in male Sprague-Dawley rats (~300 g) implanted with cortical electroencephalographic (EEG) electrodes prior to testing. Animals received four subcutaneous injections of MA, MDMA, or Foxy (10 mg/kg each as freebase, administered every 2 h), or saline as these doses produce lasting effects on learning, memory, and monoamines. EEG tracings were recorded before, during, and after treatment. Animals receiving MDMA showed no significant EEG abnormalities or myoclonus. MA treatment resulted in myoclonic activity and in brief ( |
| Databáze: | OpenAIRE |
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