Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration
Autor: | Melissa Kristocheck, Andreia Koche, Bruna Eibel, Melissa Medeiros Markoski, Maximiliano Isoppo Schaun, Luana Machado, Grasiele Sausen |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty lcsh:Internal medicine Angiogenesis business.industry Cell Biology Disease Review Article 030204 cardiovascular system & hematology Bioinformatics Clinical trial Cell therapy 03 medical and health sciences Paracrine signalling 030104 developmental biology 0302 clinical medicine medicine Autocrine signalling business lcsh:RC31-1245 Molecular Biology Homing (hematopoietic) Adult stem cell |
Zdroj: | Stem Cells International, Vol 2016 (2016) Stem Cells International |
ISSN: | 1687-9678 |
Popis: | The incidence of severe ischemic heart disease caused by coronary obstruction has progressively increased. Alternative forms of treatment have been studied in an attempt to regenerate myocardial tissue, induce angiogenesis, and improve clinical conditions. In this context, cell therapy has emerged as a promising alternative using cells with regenerative potential, focusing on the release of paracrine and autocrine factors that contribute to cell survival, angiogenesis, and tissue remodeling. Evidence of the safety, feasibility, and potential effectiveness of cell therapy has emerged from several clinical trials using different lineages of adult stem cells. The clinical benefit, however, is not yet well established. In this review, we discuss the therapeutic potential of cell therapy in terms of regenerative and angiogenic capacity after myocardial ischemia. In addition, we addressed nonpharmacological interventions that may influence this therapeutic practice, such as diet and physical training. This review brings together current data on pharmacological and nonpharmacological approaches to improve cell homing and cardiac repair. |
Databáze: | OpenAIRE |
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