| Autor: |
Tianfu Zhang, Xiaoyu Chen, Congmin Yuan, Xiaobin Pang, Ping Shangguan, Yisheng Liu, Lulu Han, Jianwei Sun, Jacky W. Y. Lam, Yang Liu, Jiefei Wang, Bingyang Shi, Ben Zhong Tang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Angewandte Chemie (International ed. in English). 62(2) |
| ISSN: |
1521-3773 |
| Popis: |
Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent β-amyloid (Aβ) fibrosis encounter failures due to the blood-brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near-infrared (NIR) aggregation-induced emission (AIE) probe, DNTPH, via balanced hydrophobicity-hydrophilicity strategy. DNTPH binds selectively to Aβ fibrils with a high signal-to-noise ratio. In vivo imaging revealed its excellent BBB permeability and long-term tracking ability with high-performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on Aβ fibrosis and promotes fibril disassembly, thereby attenuating Aβ-induced neurotoxicity. DNTPH treatment significantly reduced Aβ plaques and rescued learning deficits in AD mice. Thus, DNTPH serves as the first AIE in vivo theranostic agent for real-time NIR imaging of Aβ plaques and AD therapy simultaneously. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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