Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study
Autor: | Jinya Sato, Takefumi Ueno, Naoya Oribe, Hironori Kuga, Junichi Takahashi, Toshiaki Onitsuka, Akio Hiwatashi, Shogo Hirano, Osamu Togao, Yoji Hirano, Noriaki Hirakawa, Tomohiro Nakao, Itta Nakamura |
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Rok vydání: | 2021 |
Předmět: |
hippocampus
Planum temporale lcsh:Medicine Medicine (miscellaneous) Hippocampal formation Article 03 medical and health sciences 0302 clinical medicine Gyrus Region of interest Medicine Hippocampus (mythology) Bipolar disorder bipolar disorder medicine.diagnostic_test business.industry lcsh:R Magnetic resonance imaging medicine.disease 030227 psychiatry schizophrenia volume reduction medicine.anatomical_structure Schizophrenia business Nuclear medicine 030217 neurology & neurosurgery MRI |
Zdroj: | Journal of Personalized Medicine Volume 11 Issue 2 Journal of Personalized Medicine, Vol 11, Iss 121, p 121 (2021) |
ISSN: | 2075-4426 |
Popis: | Since patients with schizophrenia (SZ) and bipolar disorder (BD) share many biological features, detecting biomarkers that differentiate SZ and BD patients is crucial for optimized treatments. High-resolution magnetic resonance imaging (MRI) is suitable for detecting subtle brain structural differences in patients with psychiatric disorders. In the present study, we adopted a neuroanatomically defined and manually delineated region of interest (ROI) method to evaluate the amygdalae, hippocampi, Heschl’s gyrus (HG), and planum temporale (PT), because these regions are crucial in the development of SZ and BD. ROI volumes were measured using high resolution MRI in 31 healthy subjects (HS), 23 SZ patients, and 21 BD patients. Right hippocampal volumes differed significantly among groups (HS > BD > SZ), whereas left hippocampal volumes were lower in SZ patients than in HS and BD patients (HS = BD > SZ). Volumes of the amygdalae, HG, and PT did not differ among the three groups. For clinical correlations, there were no significant associations between ROI volumes and demographics/clinical symptoms. Our study revealed significant lower hippocampal volume in patients with SZ and BD, and we suggest that the right hippocampal volume is a potential biomarker for differentiation between SZ and BD. |
Databáze: | OpenAIRE |
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