Inhibition of lung damage caused by paraquat with lymphokines or cytokines
| Autor: | A. Selypes, P. Serényi, K. Barabás |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Lung Diseases
Male Paraquat Mice Inbred Strains Thymus Gland Lung injury Pathology and Forensic Medicine Biological Factors Mice chemistry.chemical_compound medicine Animals Active ingredient Lymphokines Lung biology Lung fibrosis Lymphokine Biological activity Fibrosis medicine.anatomical_structure chemistry Concanavalin A Immunology biology.protein Cytokines Cell Division Spleen |
| Zdroj: | Experimental Pathology. 38:189-195 |
| ISSN: | 0232-1513 |
| DOI: | 10.1016/s0232-1513(11)80208-2 |
| Popis: | Summary Gramoxone®, containing paraquat as an active ingredient can cause severe lung injury in both humans and experimental animals. Biologically active fibroblast-stimulating factors produced by lymphocytes and macrophages may be of importance in the development of interstitial fibrosis. In our present study we have attempted to inhibit the process of paraquat induced lung fibrosis by lymphokine-enriched supernatants from concanavalin A stimulated spleen cell cultures. It was found that adequate supernatant treatment significantly reduced PQ-induced lung injury and its associated inflammatory response. |
| Databáze: | OpenAIRE |
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