Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis
| Autor: | Yao-dong Jiang, Juan Wang, Shao-bin Zheng, Chen T, Li Wt, Chen Pl, Peng Wu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male medicine.medical_specialty Gene Expression Bioinformatics Polymorphism Single Nucleotide White People Prostate cancer Asian People Gene Frequency Prostate Risk Factors Internal medicine Genotype Genetics Genetic predisposition Odds Ratio Medicine Humans Genetic Predisposition to Disease Molecular Biology Alleles Methylenetetrahydrofolate Reductase (NADPH2) biology business.industry Case-control study Prostatic Neoplasms General Medicine Odds ratio medicine.disease medicine.anatomical_structure Meta-analysis Methylenetetrahydrofolate reductase Case-Control Studies biology.protein business |
| Zdroj: | Genetics and molecular research : GMR. 14(4) |
| ISSN: | 1676-5680 |
| Popis: | Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched for published case-control studies evaluating the association between C677T (or A1298C) and prostate cancer risk. Pooled associations were presented as odds ratios (ORs) along with their 95% confidence intervals. Twenty-one case control studies were identified for meta-analysis that included 21,581 participants. No significant associations were found between the MTHFR polymorphisms C677T or A1298C and prostate cancer risk in our meta-analysis. However, in subgroup analyses, the C677T CT polymorphism was associated with increased prostate cancer risk in East Asians (CT vs CC+TT: OR = 1.324, P = 0.03). The A1298C CC polymorphism in MTHFR was also linked to slightly reduced prostate cancer risk in European residents (CC vs AC+AA: OR = 0.751, P = 0.004; CC vs AA: OR = 0.768, P = 0.011), whereas it was associated with a significantly increased prostate cancer risk in Asian residents (CC vs AA: OR = 1.862, P = 0.006). The C677T CT polymorphism of MTHFR may be a risk factor for prostate cancer in East Asians. The association between the MTHFR A1298C CC genotype and prostate cancer risk may vary within different populations. Large-scale well-designed studies are required to confirm these associations. |
| Databáze: | OpenAIRE |
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