Influence of Antihistamines on Basophil Activation Test in Food Allergy to Milk and Egg
| Autor: | Marilena La Sorda, Antonio Gasbarrini, Angela Rizzi, Manuela Ferraironi, Maurizio Sanguinetti, Eleonora Nucera, Rosario Nicotra, Giuseppe Parrinello, Anna Giulia Ricci, Riccardo Inchingolo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
antihistamines medicine.medical_treatment Clinical Biochemistry α-lactoalbumin Basophil β-lactoglobulin medicine.disease_cause casein Article 03 medical and health sciences 0302 clinical medicine Allergen Food allergy antiallergic drugs Medicine Ingestion Contraindication food allergy lcsh:R5-920 egg white business.industry digestive oral and skin physiology Settore MED/09 - MEDICINA INTERNA medicine.disease egg yolk Basophil activation 030104 developmental biology medicine.anatomical_structure 030228 respiratory system BAT reactivity basophil activation test Immunology Antihistamine business lcsh:Medicine (General) Egg white |
| Zdroj: | Diagnostics, Vol 11, Iss 44, p 44 (2021) Diagnostics Volume 11 Issue 1 |
| ISSN: | 2075-4418 |
| Popis: | Background: The basophil activation test (BAT) is used to improve the accuracy of food allergy diagnosis. To date, the influence of antiallergic drugs on BAT reactivity is poorly investigated. The aim of the study was to investigate if BAT results were influenced by antihistamine intake for 3 months in a cohort of patients with IgE-mediated food allergy to milk or egg. Methods: A retrospective, single-center, observational study was performed. We enrolled subjects with history of hypersensitivity reaction after specific food ingestion, positive skin prick tests and specific IgEs, concomitant allergic rhinitis, and, contraindication to the double-blind, placebo-controlled food challenge due to personal history of systemic reactions related to the ingestion of culprit food. Validated allergens (&alpha lactoalbumin, &beta lactoglobulin, casein, egg white, and yolk) for BAT were used. Results: Thirty-nine patients with well-documented food symptoms and positive allergological workup were included in the study. BAT was positive in 29 patients. The mean percentages of CD63+ expression to specific culprit allergen did not change after the administration of drugs. Conclusions: This was the first study assessing the effects of oral antihistamines on basophil reactivity in cow&rsquo s milk and egg food allergy. Antihistamines do not interfere with BAT results. |
| Databáze: | OpenAIRE |
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