Afobazole Modifies the Neurotoxic and Genotoxic Effects in Rat Prenatal Alcoholization Model
| Autor: | E. D. Shreder, Andrey D. Durnev, S. B. Seredenin, V. V. Zabrodina, O. V. Shreder |
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| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty animal structures Morpholines Apoptosis Biology Protective Agents General Biochemistry Genetics and Molecular Biology Andrology chemistry.chemical_compound Pregnancy Animals Outbred Strains medicine Animals Ethanol Brain Embryo Prenatal ethanol General Medicine Embryo Mammalian Embryonic stem cell Rats Alcoholism chemistry Prenatal Exposure Delayed Effects Gestation Benzimidazoles Female Comet Assay Antimutagen DNA Damage |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 157:492-495 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Prenatal ethanol leads to the formation of a wide spectrum of neurotoxic injuries to the brain in embryos by day 20 of intrauterine development. High levels of DNA aberrations and apoptotic comets were detected in tissues of 13-day embryos and placentas of rats receiving 40% ethanol orally (4 ml/kg) during gestation. The increase in the levels of DNA aberrations and apoptotic comets in the embryonic and placental tissues of alcoholic rats on day 13 of gestation correlated with the emergence of morphological abnormalities of the brain in the embryos on day 20 of intrauterine development. Afobazole (antimutagen) in doses of 1 and 10 mg/kg reduced the genotoxic effects of ethanol in embryonic and placental tissues and the relevant neurotoxic involvement of the brain. |
| Databáze: | OpenAIRE |
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