m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
| Autor: | Fei Gao, Qingxia Li, Huajun Qu, Dongwen Rong, Qian Dong, Ping Sun, Xinna Deng |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Immunology Endogeny Apoptosis Biology medicine.disease_cause lcsh:RC254-282 Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Breast cancer Downregulation and upregulation medicine lcsh:QH573-671 YY1 lcsh:Cytology Cancer RNA Cell Biology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis Cancer research Carcinogenesis |
| Zdroj: | Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021) Cell Death Discovery |
| ISSN: | 2058-7716 |
| Popis: | Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N6-methyladenosine (m6A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m6A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m6A-mediated LINC00958 regulates BC tumorigenesis. |
| Databáze: | OpenAIRE |
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