Hepatic intra-arterial infusion of vincristine
| Autor: | David A. Albertson, Tony R. Long, Charles L. Spurr, J. Michael Sterchi, Frederick Richards, Don V. Jackson, Duff A. Rardin |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Cancer Research Vincristine Continuous infusion medicine.medical_treatment Metastatic liver cancer Toxicology Hepatic Artery medicine Humans Infusions Intra-Arterial Pharmacology (medical) Aged Pharmacology Chemotherapy business.industry Liver Neoplasms Intra arterial infusion Middle Aged Oncology Total dose Anesthesia Toxicity Female business Perfusion medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 13:120-122 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/bf00257127 |
| Popis: | Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered daily for 5 days via a hepatic artery catheter to each of six patients with metastatic liver cancer. Transient but life-threatening toxicity principally involving the nervous and gastrointestinal systems occurred in five of them. Future investigation of hepatic intra-arterial infusion of vincristine should be based on dose-schedules other than that employed in the current trial. |
| Databáze: | OpenAIRE |
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