| Popis: |
Recent work reported the existence of a mammalian cell‐autonomous antiviral defence based on RNA interference (RNAi), which relies on the accumulation of virus‐derived small interfering RNAs (vsiRNAs) to guide the degradation of complementary viral RNAs. In a new study, Zhang et al (2022) find that, in infected mice, vsiRNAs can enter the bloodstream via their incorporation into extracellular vesicles (EVs) and confer sequence‐specific antiviral activity to recipient cells, thus indicating that mammalian antiviral RNAi participates in both cell‐autonomous and non‐cell‐autonomous host defence. |
Plný text