Evidence for a link between TNFRSF11A and risk of breast cancer
| Autor: | María E. Sáez, Javier Benitez, Conxi Lázaro, Adriana Lasa, Miguel Angel Pujana, Paolo Radice, Yael Laitman, Judith Balmaña, Núria Bonifaci, Pedro Pérez-Segura, Orland Diez, Trinidad Caldés, Bella Kaufman, Miguel de la Hoya, Eitan Friedman, Victor Moreno, Loris Bernard, Siranoush Manoukian, Joan Brunet, Ander Urruticoechea, Gaia Roversi, Teresa Ramón y Cajal, Fina Climent, Monica Barile, Roni Milgrom, María Dolores Miramar, Frederique Mariette, Pasquale Pellegrini, Bernard Peissel, Paolo Peterlongo, Ana Osorio, Daniela Zaffaroni, Alessandra Viel, Eva González-Suárez, Maria Teresa Soler, Marta Palafox, Ignacio Blanco |
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| Přispěvatelé: | Bonifaci, N, Palafox, M, Pellegrini, P, Osorio, A, Benítez, J, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Roversi, G, Barile, M, Viel, A, Mariette, F, Bernard, L, Radice, P, Kaufman, B, Laitman, Y, Milgrom, R, Friedman, E, Sáez, M, Climent, F, Soler, M, Diez, O, Balmaña, J, Lasa, A, Ramón y. Cajal, T, Miramar, M, De la Hoya, M, Pérez Segura, P, Caldés, T, Moreno, V, Urruticoechea, A, Brunet, J, Lázaro, C, Blanco, I, Pujana, M, González Suárez, E |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Heterozygote Cancer Research medicine.medical_specialty BRCA1/2 mutation carriers Colorectal cancer Population Proliferation Breast Neoplasms Genome-wide association study Ligand Biology medicine.disease_cause Colorectal-Cancer RANK Cohort Studies Genome-Wide Association Breast cancer Internal medicine Odds Ratio medicine Humans Genetic Predisposition to Disease education Bone BRCA2 Protein education.field_of_study Receptor Activator of Nuclear Factor-kappa B BRCA1 Protein Hazard ratio TNFRSF11A Rankl Odds ratio medicine.disease Osteoclastogenesi RANKL Susceptibility Differentiation Mutation Immunology biology.protein Female Resolution Carcinogenesis |
| Zdroj: | BREAST CANCER RESEARCH AND TREATMENT r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0167-6806 |
| Popis: | Intracellular signaling mediated by the receptor activator of nuclear factor-κB [Rank, encoded by the tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a) gene] is fundamental for mammary gland development in mice, regulating the expansion of stem and progenitor cell compartments. Conversely, Rank overexpression in mice promotes abnormal proliferation and impairs differentiation, leading to an increased incidence of tumorigenesis. Here, we show that a common genetic variant near the 5′-end of TNFRSF11A, rs7226991, is associated with breast cancer risk in the general population and among carriers of mutations in the breast cancer 2, early onset (BRCA2) gene. Akin to the results of the Cancer and Genetics Markers of Susceptibility initiative, combined analysis of rs7226991 in two Spanish case–control studies (1,365 controls and 1,323 cases in total) revealed a significant association with risk: odds ratio (OR) = 0.88, 95% confidence interval (CI) 0.78–0.98, P trend = 0.025. Subsequent examination of BRCA1 (n = 1,017) and BRCA2 (n = 885) mutation carriers revealed a consistent association in the latter group: weighted hazard ratio (wHR) = 0.70; 95% CI 0.55–0.88; and P trend = 0.003; compared to BRCA1 mutation carriers, wHR = 0.91; 95% CI 0.76–1.10; and P trend = 0.33. The results of this study need to be replicated in other populations and with larger numbers of BRCA1/2 mutation carriers. |
| Databáze: | OpenAIRE |
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