| Popis: |
To assess the antipyretic and hepatoprotective effects of Rhynchosia cana (Wild.) DC (R. cana) methanol extract in In-silico trials and laboratory animal models. R. cana methanol extract (MERC) was evaluated for antipyretic activity in yeast-induced Pyrexia. R. cana's hepatoprotective ability was evaluated for hepatotoxicity-induced paracetamol albino rats. The GC-MS eluted compound on the protein TGF-β, and PPARα was conducted in silico docking experiments. At doses of 200 and 400 mg/kg, p.o, a single administration of MERC demonstrated strong antipyretic efficacy in albino rats. When the MERC (400 mg/kg) was given preventively for seven days, highly significant hepatoprotective behaviour was also observed. The docking findings of the TGF-β ligand molecule show that the binding affinity of vitexin is -10.3 Kcal/mol, and Silymarin is -10.6 Kcal/mol. Vitexin displayed a binding affinity of -8.8 Kcal/mol for the PPAR alpha protein, and Silymarin showed an affinity of -8.2 kcal/mol. The present research indicates that MERC has substantial antipyretic and hepatoprotective effects, as confirmed in the In Silico and In Vivo tests. |
