Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats
| Autor: | Andrew J. Gow, G. S. Ellis, S. Lanza-Jacoby, Zebulon V. Kendrick |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Physiology Physical Exertion Adipose tissue Rats Sprague-Dawley chemistry.chemical_compound Physiology (medical) Internal medicine Adipocyte Male rats medicine Animals Muscle Skeletal Triglycerides chemistry.chemical_classification Lipoprotein lipase Estradiol Body Weight Fatty Acids nutritional and metabolic diseases Fatty acid Lipid metabolism Lipid Metabolism Rats Lipoprotein Lipase Endocrinology chemistry Adipose Tissue lipids (amino acids peptides and proteins) Lipoprotein lipase activity hormones hormone substitutes and hormone antagonists Intracellular |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 77(1) |
| ISSN: | 8750-7587 |
| Popis: | The effects of 17 beta-estradiol 3-benzoate (10 micrograms.0.1 ml sunflower oil-1 x 100 g body wt-1) and exercise on tissue lipid content and lipoprotein lipase (LPL) activity were determined in male rats. Estradiol administration significantly (P < 0.05) increased fatty acid contents of resting adipose, plasma, and white and red vastus muscle tissues and red vastus muscle triacylglycerol. Adipose and plasma fatty acids and red and white vastus muscle triacylglycerol were significantly higher in exercised estradiol-administered animals than in exercised oil-administered animals. Estradiol administration significantly reduced resting adipocyte LPL activity by 71% and increased myocardial LPL activity by 96%. After exercise, red vastus LPL activity was significantly increased by 76% in estradiol-administered animals compared with oil-administered animals. Ratios of red vastus to adipose LPL activity and myocardial to adipose LPL activity at rest and after exercise were significantly greater in estradiol-administered than in oil-administered animals. Estradiol administration significantly increased the ratio of white vastus to adipose LPL activity of exercised animals. These data indicate that estradiol increases the availability of lipid substrate to exercising muscle from multiple sources, including adipose, plasma, and intracellular muscle triacylglycerol. The absolute increases in muscle LPL activity, combined with a greater ratio of muscle to adipose LPL activity, lead to increased distribution of plasma triacylglycerol-derived fatty acids toward muscle. |
| Databáze: | OpenAIRE |
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