Biotransformation of the Cyanobacterial Hepatotoxin Microcystin-LR, as Determined by HPLC and Protein Phosphatase Bioassay
| Autor: | Phillip M. Fedorak, Angeline K.-Y. Lam, Ellie E. Prepas |
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| Rok vydání: | 2011 |
| Předmět: |
Cyanobacteria
education.field_of_study biology Toxin Population Hepatotoxin Microcystin-LR General Chemistry biology.organism_classification medicine.disease_cause chemistry.chemical_compound Biochemistry chemistry Biotransformation medicine Environmental Chemistry Bioassay Microcystis aeruginosa education |
| Zdroj: | Environmental sciencetechnology. 29(1) |
| ISSN: | 0013-936X |
| Popis: | Microcystin-LR (MCLR) is a cyclic hepatotoxin and tumor promotor produced by some freshwater cyanobacteria. The occurrence of microcystin-containing blooms in freshwater has been implicated in animal and human poisonings worldwide. To assess the fate of MCLR in a heterotrophic microbial population, purified MCLR was incubated with a microbial community orginating from the Edmonton wastewater treatment plant. After 10 days of aerobic incubation, a significant decrease in MCLR concentration was observed. Analysis of the culture supernatant by highperformance liquid chromatograph, monitoring absorbance at 210 and 238 nm, suggested that the heptapeptide ring of MCLR and its Adda group had been modified, respectively |
| Databáze: | OpenAIRE |
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