Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women
| Autor: | Kathryn Wekselman, Patricia Bearnson, Sheila O'Neill, Arthur Waldbaum, Leonard R. Derogatis, Akshay Buch, Michèle Moreau, Norman Kakos, Robin Kroll, Jan L. Shifren, Susan R. Davis, Cynthia Rodenberg, Stephen Levine, Céline Bouchard, Christine Derzko |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Sexual Behavior Population Physiology Administration Cutaneous Placebo Sex hormone-binding globulin Double-Blind Method Humans Medicine Testosterone Sexual Dysfunctions Psychological education Aged Libido Gynecology education.field_of_study biology business.industry Obstetrics and Gynecology Testosterone (patch) Hypoactive sexual desire disorder Middle Aged medicine.disease Sexual desire Treatment Outcome Estrogen Androgens biology.protein Female Menopause business |
| Zdroj: | Monash University |
| ISSN: | 1072-3714 |
| DOI: | 10.1097/01.gme.0000243567.32828.99 |
| Popis: | OBJECTIVE To evaluate the efficacy and safety of a testosterone patch for the treatment of women with hypoactive sexual desire disorder after natural menopause. DESIGN A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial was conducted in naturally menopausal women with hypoactive sexual desire disorder receiving a stable dose of oral estrogen with or without progestin (N = 549). Women were randomized to receive testosterone 300 microg/day or placebo patches twice weekly for 24 weeks. The primary efficacy measure was change from baseline in frequency of total satisfying sexual activity over a 4-week period (weeks 21-24). RESULTS A total of 483 women (88%) were included in the primary analysis population (those with baseline sex hormone binding globulin levels < or = 160 nmol/L). The change from baseline in number of total satisfying sexual episodes was significantly greater for testosterone compared with placebo (participants with baseline sex hormone binding globulin levels < or = 160 nmol/L, mean change of 2.1 +/- 0.28 versus 0.5 +/- 0.23 episodes/4 weeks; P < 0.0001; intent-to-treat population, mean change from baseline of 1.9 +/- 0.26 versus 0.5 +/- 0.21 episodes/4 weeks, P < 0.0001). Testosterone also produced statistically significant improvements compared with placebo in all secondary efficacy measures, including sexual desire and personal distress. The testosterone patch was well tolerated. CONCLUSIONS Testosterone patch treatment increased the frequency of satisfying sexual activity and sexual desire, decreased personal distress, and was well tolerated in naturally menopausal women with hypoactive sexual desire disorder. |
| Databáze: | OpenAIRE |
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