Effect of oral anticoagulants on the outcome of faecal immunochemical test
| Autor: | Maria Sala, JONE MIREN ALTZIBAR, Isabel Portillo, Manuel Hernandez-Guerra, Luis Bujanda, Maria Lopez-Ceron, Javier Pérez Gisbert, Francesc Macià, Vicent Hernandez, Xavier Bessa Caserras, Guillermo Cacho Acosta, Jaume Grau, Francesc Balaguer, JOAQUIN CUBIELLA, Cecilio Santander Vaquero, Leticia Moreira, Inmaculada Salces, Antoni Castells, Alicia C. Marin, Jose Diaz-Tasende, Jose m Enriquez-navascues, Blanca Rodriguez, Renata Linertová, Pablo Vega, Enrique Quintero |
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| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Colorectal cancer Short Communication Population Colonoscopy colorectal cancer screening Gastroenterology law.invention Randomized controlled trial oral anticoagulant law Càncer colorectal Internal medicine medicine Humans Mass Screening education Early Detection of Cancer Mass screening Gynecology Aspirin education.field_of_study medicine.diagnostic_test business.industry Immunochemistry Anticoagulants Colonoscòpia Odds ratio Middle Aged FIT medicine.disease Clopidogrel faecal immunochemical test Immunoquímica Oncology Estudi de casos Occult Blood advanced neoplasia Anticoagulants (Medicina) Female Case studies Anticoagulants (Medicine) Colorectal Neoplasms business medicine.drug |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname British Journal of Cancer Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| Popis: | Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75¿ng¿ml–1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4–10.8; P=0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets. |
| Databáze: | OpenAIRE |
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