Multimeric cyclam derivatives with tunable surface modification for radiopharmaceutical applications

Autor:	Anika Röhrich, Holger Stephan, Jörg Steinbach, Manja Kuhlmann
Rok vydání:	2010
Předmět:	copper-64 Cancer Research chemistry.chemical_compound chemistry Cyclam multimers Molecular Medicine Surface modification Radiology Nuclear Medicine and imaging cyclam Combinatorial chemistry peptide
Zdroj:	Nuclear Medicine and Biology 37(2010)6, 681 International Symposium on Technetium and other Radiometals in Chemistry and Medicine, 08.-11.09.2010, Bressanone, Italy Ulderico Mazzi, William V. Eckelman, Wynn A. Volkert: Technetium and Other Radiometals in Chemistry and Medicine, Padova: SGEditoriali, 2010, 77-80
ISSN:	0969-8051
DOI:	10.1016/j.nucmedbio.2010.04.066
Popis:	1,4,8,11-Tetraazacyclotetradecane (cyclam) derivatives with one to four appending dipeptide residues (Arg-Tyr) have been synthesized. Kinetics of complex formation with copper(II) was investigated by UV/vis spectroscopy to show a deceleration with increasing substitution degree of the cyclam core. Radiolabeling experiments with 64CuII on the peptide tetramer 5 revealed a smooth and efficient complexation. Challenge studies of 64Cu5 in the presence of cyclam as competing ligand prove the high kinetic inertness of the radiocopper(II) complex formed with 5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1008e342ce87712f9f4b945baeb5f808 https://doi.org/10.1016/j.nucmedbio.2010.04.066 Zobrazit plný text záznamu Full Text from ScienceDirect