Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam
| Autor: | Petra J. M. Elders, Jan Kluytmans, Andreas M. Kaiser, N. al Naiemi, Paul H. M. Savelkoul, E. A. Reuland, Max Heck, Christina M. J. E. Vandenbroucke-Grauls |
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| Přispěvatelé: | Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA Medische Microbiologie en Infectieziekten (5), RS: CAPHRI - R4 - Health Inequities and Societal Participation, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, Medical Microbiology and Infection Prevention, AII - Infectious diseases, General practice, EMGO - Lifestyle, overweight and diabetes |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Veterinary medicine Cross-sectional study chemistry.chemical_compound 0302 clinical medicine SPECTRUM-BETA-LACTAMASE Risk Factors Epidemiology 80 and over Prevalence polycyclic compounds Pharmacology (medical) 030212 general & internal medicine Amplified Fragment Length Polymorphism Analysis CTX-M Non-U.S. Gov't Netherlands Original Research Aged 80 and over education.field_of_study Research Support Non-U.S. Gov't Enterobacteriaceae Infections HUMANS Middle Aged COMMUNITY Infectious Diseases PCR ESCHERICHIA-COLI Population Surveillance Carrier State Female Ertapenem Microbiology (medical) Adult medicine.medical_specialty GENES Adolescent 030106 microbiology Population Microbial Sensitivity Tests Research Support beta-Lactam Resistance beta-Lactamases 03 medical and health sciences Young Adult Enterobacteriaceae Environmental health Journal Article medicine Humans Typing Risk factor education Aged Pharmacology business.industry biochemical phenomena metabolism and nutrition bacterial infections and mycoses TRENDS Carriage Cross-Sectional Studies chemistry Case-Control Studies Multilocus sequence typing bacteria CHICKEN MEAT business Multilocus Sequence Typing |
| Zdroj: | Journal of Antimicrobial Chemotherapy, 71(4), 1076-1082. Oxford University Press Journal of Antimicrobial Chemotherapy Reuland, E A, Al Naiemi, N, Kaiser, A M, Heck, M, Kluytmans, J A J W, Savelkoul, P H M, Elders, P J M & Vandenbroucke-Grauls, C M J E 2016, ' Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam ', Journal of Antimicrobial Chemotherapy, vol. 71, no. 4, pp. 1076-82 . https://doi.org/10.1093/jac/dkv441 Journal of Antimicrobial Chemotherapy, 71(4), 1076-82. Oxford University Press Journal of Antimicrobial Chemotherapy, 71(4), 1076. Oxford University Press |
| ISSN: | 0305-7453 |
| Popis: | OBJECTIVES: The objectives of this study were to determine the prevalence of carriage of ESBL-producing Enterobacteriaceae (ESBL-E) in a representative sample of the general adult Dutch community, to identify risk factors and to gain understanding of the epidemiology of these resistant strains.METHODS: Adults enrolled in five general practices in Amsterdam were approached by postal mail and asked to fill in a questionnaire and to collect a faecal sample. Samples were analysed for the presence of ESBL-E. ESBL genes were characterized by PCR and sequencing. Strains were typed using MLST and amplified fragment length polymorphism (AFLP) and plasmids were identified by PCR-based replicon typing. Risk factors for carriage were investigated by multivariate analysis.RESULTS: ESBL-E were found in 145/1695 (8.6%) samples; 91% were Escherichia coli. Most ESBL genes were of the CTX-M group (blaCTX-M-1 and blaCTX-M-15). MLST ST131 was predominant and mainly associated with CTX-M-15-producing E. coli. One isolate with reduced susceptibility to ertapenem produced OXA-48. In multivariate analyses, use of antimicrobial agents, use of antacids and travel to Africa, Asia and Northern America were associated with carriage of ESBL-E, in particular strains with blaCTX-M-14/15.CONCLUSIONS: This study showed a high prevalence of ESBL-E carriage in the general Dutch community. Also, outside hospitals, the use of antibiotics was a risk factor; interestingly, use of antacids increased the risk of carriage. A major risk factor in the general population was travel to countries outside Europe, in particular to Asia, Africa and Northern America. |
| Databáze: | OpenAIRE |
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