Roles of Microglial Ion Channel in Neurodegenerative Diseases
| Autor: | Alexandru Cojocaru, Eugen Osiac, Emilia Burada, Aurel Popa-Wagner, Alexandru-Florian Deftu, Bogdan Catalin, Adrian-Tudor Bălșeanu |
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| Rok vydání: | 2021 |
| Předmět: |
Lateral amyloid sclerosis
Phagocytosis Central nervous system Medizin lcsh:Medicine microglia Review multiple sclerosis cerebral ischemia 03 medical and health sciences 0302 clinical medicine parkinson disease Medicine Receptor Neuroinflammation Ion channel 030304 developmental biology 0303 health sciences Microglia business.industry Multiple sclerosis lcsh:R Neurodegeneration neurodegeneration alzheimer’s disease General Medicine medicine.disease medicine.anatomical_structure ion channel epilepsy business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 1239, p 1239 (2021) |
| ISSN: | 2077-0383 |
| Popis: | As the average age and life expectancy increases, the incidence of both acute and chronic central nervous system (CNS) pathologies will increase. Understanding mechanisms underlying neuroinflammation as the common feature of any neurodegenerative pathology, we can exploit the pharmacology of cell specific ion channels to improve the outcome of many CNS diseases. As the main cellular player of neuroinflammation, microglia play a central role in this process. Although microglia are considered non-excitable cells, they express a variety of ion channels under both physiological and pathological conditions that seem to be involved in a plethora of cellular processes. Here, we discuss the impact of modulating microglia voltage-gated, potential transient receptor, chloride and proton channels on microglial proliferation, migration, and phagocytosis in neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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