Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review
| Autor: | Kahynna Cavalcante Loureiro, Eliana B. Souto, Ana Cláudia Santos, Ricardo Guimarães Amaral, Rafael Silva Santos, Patrícia Severino, Damião Pergentino de Sousa, Raquel de Melo Barbosa, Antonello Santini, Luciana Nalone Andrade, Classius Ferreira da Silva, Polyana Rezende |
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| Přispěvatelé: | Santos, R. S., Loureiro, K. C., Rezende, P. S., Andrade, L. N., de Melo Barbosa, R., Santini, A., Santos, A. C., Ferreira da Silva, C., Souto, E. B., de Sousa, D. P., Amaral, R. G., Severino, P. |
| Rok vydání: | 2018 |
| Předmět: |
skin
Antifungal Agents Antifungal drugs Nanotechnology Dermatology Administration Cutaneous Therapeutic drug effect Skin Diseases cutaneous drug delivery 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Oral administration Medicine Humans Topical route Adverse effect Beneficial effects 030203 arthritis & rheumatology Drug Carriers antifungal drug business.industry fungal infection Bioavailability Nanostructures Nanomedicine Mycoses Liposomes business |
| Zdroj: | The Journal of dermatological treatment. 30(6) |
| ISSN: | 1471-1753 |
| Popis: | Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect. The topical route is desirable due to the adverse effects arising from oral administration. This review provides a comprehensive analysis of the use of nano compounds for the current treatment of topical fungal infections. A special emphasis is given to the employment of lipid nanoparticles, due to their recognized efficacy, versatility, and biocompatibility, attracting the major attention as novel topical nanocompounds used for the administration of antifungal drugs. |
| Databáze: | OpenAIRE |
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