Timing of Insulin Basal Rate Reduction to Reduce Hypoglycemia During Late Postprandial Exercise in Adults with Type 1 Diabetes Using Insulin Pump Therapy: A Randomized Crossover Trial
| Autor: | Virginie Messier, S. Elbekri, Nadine Taleb, C. Cameli, Mohamed Raef Smaoui, Rémi Rabasa-Lhoret, Corinne Suppère, Martin Ladouceur, Amélie Roy-Fleming, Laurent Legault |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male Insulin pump medicine.medical_specialty Basal rate Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Hypoglycemia Post-prandial Young Adult 03 medical and health sciences Insulin Infusion Systems 0302 clinical medicine Endocrinology Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Insulin In patient Exercise Aged Type 1 diabetes Cross-Over Studies business.industry General Medicine Middle Aged Postprandial Period medicine.disease Crossover study Diabetes Mellitus Type 1 Postprandial Anesthesia Female business |
| Zdroj: | Canadian Journal of Diabetes. 42:S52 |
| ISSN: | 1499-2671 |
| Popis: | To compare the efficacy of three timings to decrease basal insulin infusion rate to reduce exercise-induced hypoglycaemia in patients with type 1 diabetes (T1D) using pump therapy.A single-blinded, randomized, 3-way crossover study in 22 adults that had T1D 1 year and using insulin pump 3 months (age, 40 ± 15 years; HbANo significant difference was observed for percentage of time spent 4.0 mmol/L (T-40: 16 ± 25%; T-20: 26 ± 27%; T0: 24 ± 29%) (main outcome) and time spent in target range 4.0-10.0 mmol/L (T-40: 63 ± 37%; T-20: 66 ± 25%; T0: 65 ± 31%). With T-40 strategy, although not significant, starting blood glucose (BG) was higher (T-40: 8.6 ± 3.6 mmol/L; T-20: 7.4 ± 2.5 mmol/L ; T0: 7.4 ± 2.7 mmol/L), fewer patients needed extra carbohydrates consumption prior to exercise for BG 5.0 mmol/L (T-40: n = 3; T-20: n = 5; T0: n = 6) as well as during exercise for BG 3.3 mmol/L [T-40: n = 6 (27%); T-20: n = 12 (55%); T0: n = 11 (50%)] while time to first hypoglycaemic episode was delayed (T-40: 28 ± 14 min; T-20: 24 ± 10 min; T0: 22 ± 11 min).Decreasing basal insulin infusion rate by 80% up to 40 minutes before exercise onset is insufficient to reduce exercise-induced hypoglycaemia. |
| Databáze: | OpenAIRE |
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