IL-17 Promotes Murine Lupus
| Autor: | Elaine V. Lourenço, Gil Amarilyo, Fu-Dong Shi, Antonio La Cava |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Immunology
Lupus nephritis Fluorescent Antibody Technique Enzyme-Linked Immunosorbent Assay Mice Inbred Strains T-Lymphocytes Regulatory Proinflammatory cytokine Pathogenesis Mice T-Lymphocyte Subsets immune system diseases Animals Lupus Erythematosus Systemic Immunology and Allergy Medicine skin and connective tissue diseases Autoantibodies Mice Knockout Lupus erythematosus Systemic lupus erythematosus Mice Inbred NZB Terpenes business.industry Interleukin-17 Autoantibody Flow Cytometry medicine.disease Lupus Nephritis Mice Inbred C57BL Th17 Cells Interleukin 17 business Anti-SSA/Ro autoantibodies |
| Zdroj: | The Journal of Immunology. 193:540-543 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1400931 |
| Popis: | The proinflammatory activity of IL-17–producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17–sufficient wild-type mice did not occur in IL-17–deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17–deficient mice was associated with a reduced frequency of CD3+CD4−CD8− double-negative T cells and an expansion of CD4+ regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE. |
| Databáze: | OpenAIRE |
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