| Autor: |
Harbans Lal, Joseph J. Venafro, Stuart Fielding, Theodore C. Spaulding |
| Rok vydání: |
1979 |
| Předmět: |
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| Zdroj: |
European Journal of Pharmacology. 58:19-25 |
| ISSN: |
0014-2999 |
| DOI: |
10.1016/0014-2999(79)90335-2 |
| Popis: |
The activity of clonidine and its interaction with morphine was assesed in the mouse tail flick assay. In this assay, clonidine was found to be 10 times more potent than morphine. Clonidine potentiated morphine antinociceptive activity approximately five-fold and morphine potentiated clonidine activity four-fold. Clonidine's agonistic activity was not reversed by naloxone hydrochloride 910 mg/kg) while the potentiating effect of clonindine by morphine was. Tolerance to the antinociceptive effect of morphine was observed in morphine pellet-implanted mice byt no cross tolerance was observed for clonidine. These data indicate that clonidine-induced analgesia is not a result of an interaction at morphine receptors; but rather, common pathway(s) are present which appear to complement the agonistic interaction of each. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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