Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease

Autor: Marijana Petković, Jürgen Schiller, Snežana Pejić, Dunja Drakulić, Aleksandra Stefanović, Jadranka Miletić Vukajlović, Tihomir V. Ilić
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Parkinson's disease
medicine.disease_cause
01 natural sciences
Analytical Chemistry
Lipid peroxidation
Plasma
chemistry.chemical_compound
Internal medicine
Phosphatidylcholine
Plasma lipids
PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE ACTIVITY
medicine
Humans
MALDI-TOF MS
In patient
OXIDATIVE STRESS
Spectroscopy
Aged
PHOSPHOLIPASE A(2) ACTIVITY
SUBSTANTIA-NIGRA
FATTY-ACID
010401 analytical chemistry
Organic Chemistry
Case-control study
Lysophosphatidylcholines
Parkinson Disease
MASS-SPECTROMETRY
Middle Aged
LYSOPHOSPHATIDYLCHOLINE
medicine.disease
LIPID-PEROXIDATION
O-ACYLTRANSFERASE
3. Good health
0104 chemical sciences
Lysophosphatidylcholine
Endocrinology
chemistry
Case-Control Studies
Spectrometry
Mass
Matrix-Assisted Laser Desorption-Ionization
Phosphatidylcholines
Female
lipids (amino acids
peptides
and proteins)
Oxidative stress
Zdroj: Rapid Communications in Mass Spectrometry
Popis: Rationale: Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine (LPC) ratios in patients with Parkinson's disease (PD) in comparison with healthy subjects and their correlation with clinico-pathological features. Methods: The study included 10 controls and 25 patients with PD. All patients were assigned to groups based on clinico-pathological characteristics (gender, age at examination, duration of disease and Hoehn and Yahr (H&Y) stage). The analysis of the PC/LPC intensity ratios in plasma lipid extracts was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: PD patients exhibited an increased PC/LPC intensity ratio in comparison with the control group of healthy subjects. Furthermore, the investigated ratio was shown to be correlated with clinico-pathological parameters, in particular with H&Y stage and disease duration. The PC/LPC intensity ratio in plasma samples of PD patients was found to be elevated in all examined H&Y stages and throughout the disease duration. Conclusions: To our knowledge, this is the first study examining the PC/LPC ratios in plasma of patients with PD and illustrating their correlation with clinico-pathological features. Although the presented results may be considered as preliminary due to the limited number of participants, the observed alterations of PC/LPC ratios in plasma might be a first step in the characterization of plasma lipid changes in PD patients and an indicator of lipid reconfiguration. © 2019 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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