In utero exposure to aluminium and other neurotoxic elements in urban coastal south african women at delivery: An emerging concern
| Autor: | Claudina Mca Nogueira, Kalavati Channa, Bukola Ganiyat Olutola, Halina B. Rollin, Jon Øyvind Odland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Health Toxicology and Mutagenesis neurotoxic elements lcsh:Medicine Gestational Age 010501 environmental sciences In utero exposure 01 natural sciences Article Arsenic Young Adult 03 medical and health sciences 0302 clinical medicine essential trace elements Pregnancy Environmental health medicine Humans 030212 general & internal medicine 0105 earth and related environmental sciences Rank correlation business.industry Public health aluminium lcsh:R Infant Newborn Pregnancy Outcome Public Health Environmental and Occupational Health birth outcomes Gestational age Mercury sex-dependent response to toxicants Trace Elements Maternal Exposure In utero Significant positive correlation Female business Aluminum |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 5 17:1724 International Journal of Environmental Research and Public Health (IJERPH) International Journal of Environmental Research and Public Health, Vol 17, Iss 5, p 1724 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17051724 |
| Popis: | Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its effects on birth outcomes and possible synergistic effects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman&rsquo s rank correlation coefficients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361 p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities. |
| Databáze: | OpenAIRE |
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