Reversible inhibition of DNA, RNA and protein synthesis in human cells by lead chloride
| Autor: | Yvette Škreb, Vlasta Habazin-Novak |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Cell division
biology Histocytochemistry Lead chloride RNA DNA Toxicology biology.organism_classification Cytoplasmic Granules HeLa chemistry.chemical_compound Biochemistry chemistry Lead Depression Chemical Protein Biosynthesis Protein biosynthesis Humans Reversible inhibition Cell Division Macromolecule HeLa Cells |
| Zdroj: | Toxicology. 5(2) |
| ISSN: | 0300-483X |
| Popis: | An acute intoxication by lead chloride (conc. 2.5 - 10(-4)M) produces a temporary reduction of macromolecular syntheses in HeLa cells growing asynchronously. The reduction is similar for DNA, RNA and proteins and differs only in the intensity. After a one-day intoxication, if the cells are put back in a fresh medium, the syntheses return to normal within 10 h. The histochemical sulphide-silver method shows that lead is present in the cells during the inhibition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|