THE COMBINED EFFECT OF ALCOHOL AND AMITRIPTYLINE ON SKILLS SIMILAR TO MOTOR–CAR DRIVING
| Autor: | Ali A. Landauer, Gerald Milner, Joanne Patman |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
Male Drug Automobile Driving Amitriptyline media_common.quotation_subject Poison control Alcohol Affect (psychology) Placebos chemistry.chemical_compound Injury prevention Humans Medicine Motor skill media_common Clinical Trials as Topic Ethanol business.industry Accidents Traffic Drug Synergism General Medicine medicine.disease chemistry Motor Skills Anesthesia Female Medical emergency business Psychotropic Agent medicine.drug |
| Zdroj: | Medical Journal of Australia. 2:946-949 |
| ISSN: | 1326-5377 0025-729X |
| DOI: | 10.5694/j.1326-5377.1969.tb107519.x |
| Popis: | IN A DOUBLE-BLIND STUDY, 12 NORMAL SUBJECTS WERE GIVEN AMITRIPTYLINE, IN A DOSAGE OF 50 MG EVERY 12 HOURS, FOR FIVE DAYS AND WERE TESTED BY MEANS OF A MOTOR SKILL BATTERY WITH AND WITHOUT ALCOHOL ADMINISTRATION. COMPARISONS WITH AN EQUALLY CONSTITUTED CONTROL GROUP SHOWED THAT SOME DECREMENTS IN PERFORMANCE WERE DUE TO ALCOHOL CONSUMPTION. AMITRIPTYLINE ADMINISTRATION DID NOT SIGNIFICANTLY AFFECT TEST PERFORMANCE, NOR WAS ANY SIGNIFICANT INTERACTION EFFECT NOTED. THE IMPORTANCE OF TESTING FOR INTERACTION BETWEEN THE COMMONLY PRESCRIBED PSYCHOTROPIC AGENTS AND ALCOHOL IS DISCUSSED SINCE POTENTIATION OF ALCOHOL EFFECTS MAY AT TIMES CONTRIBUTE TO TRAFFIC ACCIDENTS AND THE HAZARDS OF DRUG OVERDOSAGE. /AUTHOR/ |
| Databáze: | OpenAIRE |
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