Plasma Renin Activity Predicts the Improvement in Resistant Hypertension after Percutaneous Transluminal Renal Artery Angioplasty
| Autor: | Tomoyasu Yahagi, Toshikazu Goto, Saya Suzuki, Motoyuki Matsui, Shigehiko Kato, Yoku Kikuchi, Hyuma Daidoji, Ken Watanabe, Yoshiaki Tamada, Akio Fukui, Katsuaki Takahashi, Taku Shikama |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Percutaneous Urology Blood Pressure 030204 cardiovascular system & hematology Renal artery stenosis Kidney Renal Artery Obstruction Plasma renin activity Renovascular hypertension 03 medical and health sciences plasma renin activity 0302 clinical medicine Renal Artery Interquartile range Renin Internal Medicine medicine Humans 030212 general & internal medicine percutaneous renal artery angioplasty Antihypertensive Agents Aged Aged 80 and over renal artery stenosis business.industry Angioplasty General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Blood pressure Hypertension Renovascular Female Original Article business |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | Objective Percutaneous transluminal renal artery angioplasty (PTRA) has been recommended for the treatment of renovascular resistant hypertension. However, large randomized trials have reported that PTRA did not improve the outcomes compared with optimal medical therapy in patients with renal artery stenosis (RAS). It is important to identify patients with renovascular hypertension who are likely to respond to PTRA. We herein examined whether or not the plasma renin activity (PRA) could predict the improvement in resistant hypertension after PTRA for RAS. Methods and Results A total of 40 patients (mean age: 63±15 years) with unilateral RAS who received PTRA for resistant hypertension were enrolled in this study. Twenty-two (55%) patients experienced a significant reduction in their blood pressure while using few antihypertensive agents at the 3-month follow up. The median PRA was significantly higher in patients using few antihypertensive agents than in those using more [4.2 ng/mL/hr, interquartile range (IQR) 2.6-8.0 vs. 0.8 ng/mL/hr, IQR 0.4-1.7, p2.4 ng/mL/hr) was an independent predictor of the improvement in hypertension after PTRA (odds ratio: 22.3, 95% confidence interval: 2.17 to 65.6, p |
| Databáze: | OpenAIRE |
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