Severe cholestatic jaundice in hyperthyroidism after treatment with 131-iodine
| Autor: | William M. Tierney, Muhammad K. Hasan, M Z Baker |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.diagnostic_test business.industry Bilirubin General Medicine Autoimmune hepatitis Jaundice medicine.disease Gastroenterology Hyperthyroidism Biliary disease Iodine Radioisotopes Jaundice Obstructive Cholestasis Liver biopsy Heart failure Internal medicine medicine Thyroid storm Humans medicine.symptom Viral hepatitis business |
| Zdroj: | The American journal of the medical sciences. 328(6) |
| ISSN: | 0002-9629 |
| Popis: | A 39-year-old white man was referred to our hospital for evaluation of his jaundice and pruritus. The patient was treated with I for diffuse toxic goiter prior to his referral to our hospital. Clinical examination and laboratory investigations excluded viral hepatitis, autoimmune hepatitis, granulomatous disease, primary biliary disease, extrahepatic biliary obstruction, and heart failure. Liver biopsy showed severe intrahepatic and canalicular cholestasis with minimal inflammatory changes. The patient's jaundice promptly resolved with therapy for hyperthyroidism and thyroid storm as bilirubin levels decreased from 35 mg/dL (normal: 0.5-1.2 mg/dL) to 0.4 mg/dL. Thyrotoxicosis can be an uncommon cause of profound cholestasis. Our case differs from all other reports in the literature because of the severity of the cholestasis and its prompt resolution with treatment for thyrotoxicosis. |
| Databáze: | OpenAIRE |
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