EPA and DHA have divergent effects on serum triglycerides and lipogenesis, but similar effects on lipoprotein lipase activity: a randomized controlled trial
| Autor: | Adam H. Metherel, Alex Rajna, Maha Irfan, Richard P. Bazinet, David M. Mutch, Shannon L. Klingel, Adrian Chabowski |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Docosahexaenoic Acids Medicine (miscellaneous) Blood lipids 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Internal medicine Humans Medicine Triglycerides Lipoprotein lipase Nutrition and Dietetics Triglyceride business.industry Lipogenesis Eicosapentaenoic acid 3. Good health Lipoprotein Lipase 030104 developmental biology Endocrinology Eicosapentaenoic Acid chemistry Blood chemistry Docosahexaenoic acid Dietary Supplements Female lipids (amino acids peptides and proteins) business |
| Zdroj: | The American Journal of Clinical Nutrition. 110:1502-1509 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/nqz234 |
| Popis: | BACKGROUND Comparative studies suggest that DHA may have stronger serum triglyceride-lowering effects than EPA; however, the molecular basis for this differential effect remains unexplored in humans. Differential regulation of lipogenesis and triglyceride clearance are 2 possible mechanisms of action. OBJECTIVES We compared the effects of EPA and DHA supplementation on serum triglycerides, markers of lipogenesis, and lipoprotein lipase (LPL) activity in adults participating in a double-blind, multiarm, placebo-controlled parallel-group randomized trial. Lipogenesis was assessed with the lipogenic index and compound specific isotope analysis (CSIA). METHODS Young, healthy normolipidemic men and women (n = 89; 21.6 ± 0.23 y; mean ± SEM) were randomly allocated into 1 of 3 supplement groups for 12 wk: 1) olive oil, 2) ∼3 g EPA/d, and 3) ∼3 g DHA/d. Omega-3 supplements were provided in triglyceride form. Blood was collected before and after supplementation for the analysis of fatty acids and preheparin LPL activity. Variations in the 13C:12C ratio (δ13C) of palmitate (16:0) and linoleate (18:2n-6) were measured by CSIA. RESULTS DHA supplementation reduced blood triglycerides (0.85 ± 0.04 mmol/L to 0.65 ± 0.03 mmol/L; P |
| Databáze: | OpenAIRE |
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