Diagnostic value of WIF1 methylation for colorectal cancer: a meta-analysis
| Autor: | Xiuru Ying, Tianyi Huang, Bin Li, Tiangong Wang, Cong Zhou, Min Chen, Huihui Ji, Yong Yang, Ranran Pan, Danjie Jiang, Yanfei Chen, Yuehong Chen, Haochang Hu, Shiwei Duan |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Colorectal cancer colorectal cancer 03 medical and health sciences 0302 clinical medicine Internal medicine medicine DNA methylation Receiver operating characteristic business.industry Area under the curve Methylation medicine.disease 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis Meta-analysis Diagnostic odds ratio diagnostic value business WIF1 Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 (WIF1) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of WIF1 methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of WIF1 methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-analysis of 12 studies between 1420 CRC samples and 946 control samples showed that WIF1 hypermethylation was significantly associated with CRC (P < 0.001, OR = 30.10, 95% CI = 19.48-46.50). WIF1 hypermethylation, as a diagnostic biomarker for CRC, has a pooled sensitivity of 0.40 (95% CI: 0.37-0.42), a pooled specificity of 0.95 (95% CI: 0.93-0.96), a pooled positive-likelihood ratio (PLR) of 8.65 (95% CI, 4.47-16.73), and a pooled negative-likelihood ratio (NLR) of 0.41 (95% CI, 0.30-0.55), a diagnostic odds ratio (DOR) of 26.86 (95% CI: 15.73-45.89), and an area under the curve (AUC) of 0.9115. In conclusion, our study established that WIF1 hypermethylation might be a promising diagnostic biomarker for CRC. |
| Databáze: | OpenAIRE |
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