The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer
| Autor: | Rolando Vegliante, Luca Di Leo, Maria Rosa Ciriolo, Fabio Ciccarone |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Epigenetics
Oncometabolism TCA cycle mtDNA Adenosine Triphosphate Animals Epigenesis Genetic Gene Expression Regulation Neoplastic Humans Metabolic Networks and Pathways Mitochondria Neoplasms Citric Acid Cycle Energy Metabolism Transcriptional Activation 0301 basic medicine Cancer Research Biology 03 medical and health sciences chemistry.chemical_compound Genetic medicine Settore BIO/10 chemistry.chemical_classification Neoplastic Cancer medicine.disease Citric acid cycle Metabolic pathway 030104 developmental biology Enzyme Gene Expression Regulation Biochemistry chemistry Cancer cell Flux (metabolism) DNA Epigenesis |
| Zdroj: | Seminars in Cancer Biology. 47:50-56 |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2017.06.008 |
| Popis: | Cancer cells exploit metabolic rearrangements for sustaining their high proliferation rate and energy demand. The TCA cycle is a central metabolic hub necessary for ATP production and for providing precursors used in many biosynthetic pathways. Thus, dysregulation of the TCA cycle flux is frequently observed in cancer. The identification of mutations in several enzymes of the TCA cycle in human tumours demonstrated a direct connection between this metabolic pathway and cancer occurrence. Moreover, changes in the expression/activity of these enzymes were also shown to promote metabolic adaptation of cancer cells. In this review, the main genetic and non-genetic alterations of TCA cycle in cancer will be described. Particular attention will be given to extrametabolic roles of TCA cycle enzymes and metabolites underlying the regulation of nuclear and mitochondrial DNA transactions. |
| Databáze: | OpenAIRE |
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