Exhaled nitric oxide in asthmatic children exposed to relevant allergens: effect of flunisolide
| Autor: | Paola Mazzi, Diego Peroni, Ylenia Suzuki, L. Vicentini, Attilio Boner, Alessandro Bodini, Giorgio Piacentini, Silvia Costella |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine corticosteroid Allergy Adolescent Anti-Inflammatory Agents airway inflammation Nitric Oxide medicine.disease_cause Statistics Nonparametric Nitric oxide allergen avoidance asthma nitric oxide Mice chemistry.chemical_compound Allergen Reference Values Administration Inhalation medicine Flunisolide Animals Humans Expiration Child Asthma House dust mite Mites Dose-Response Relationship Drug biology business.industry Allergens medicine.disease biology.organism_classification Respiratory Function Tests respiratory tract diseases Treatment Outcome Breath Tests Fluocinolone Acetonide chemistry Immunology Exhaled nitric oxide Female business medicine.drug |
| Zdroj: | European Respiratory Journal. 15:730-734 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1034/j.1399-3003.2000.15d17.x |
| Popis: | Inhaled corticosteroids are capable of reducing the level of exhaled nitric oxide (expiratory nitric oxide fraction (FE,NO)) in asthmatic patients in a dose-dependent fashion. The aim of this study was to evaluate whether or not treatment with an inhaled steroid can prevent changes in FE,NO after the exposure to relevant allergens, following avoidance, in asthmatic children allergic to house dust mite. Thirty-two house dust mite-allergy asthmatic children were randomly allocated to treatment with inhaled flunisolide (500 microg b.i.d) or placebo and evaluated before and 2 weeks after a period of natural exposure to mite antigens. Lung function and FE,NO were evaluated. FE,NO was increased in the placebo-treated group after antigen exposure. Treatment with inhaled flunisolide prevented such increase in FE,NO (p |
| Databáze: | OpenAIRE |
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