Brain natriuretic peptide predicts chronic atrial fibrillation after ventricular pacing in patients with sick sinus syndrome
| Autor: | Hajime Horie, Masahiko Kinoshita, Masaru Hayashi, Kazuo Minai, Takayoshi Tsutamoto, Osamu Kito |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Physiology medicine.drug_class Hemodynamics Sick sinus syndrome Atrial natriuretic peptide Actuarial Analysis Internal medicine Atrial Fibrillation Natriuretic Peptide Brain medicine Natriuretic peptide Humans cardiovascular diseases Aged Proportional Hazards Models Sick Sinus Syndrome business.industry Cardiac Pacing Artificial Atrial fibrillation Middle Aged medicine.disease Brain natriuretic peptide SSS Survival Rate Anesthesia Chronic Disease cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor Biomarkers circulatory and respiratory physiology |
| Zdroj: | Japanese circulation journal. 64(12) |
| ISSN: | 0047-1828 |
| Popis: | Chronic atrial fibrillation (AF) is one of the main complications of sick sinus syndrome (SSS). As previously reported, plasma brain natriuretic peptide (BNP), reflects hemodynamic changes in different pacing modes, as does plasma atrial natriuretic peptide (ANP), so the present study investigated whether plasma BNP or ANP can predict chronic AF after single-chamber ventricular (VVI) pacemaker implantation in patients with SSS. Plasma ANP and BNP levels were measured before and 1-3 months after implantation in 99 SSS patients. Long-term follow-up was conducted with chronic AF as an endpoint. Chronic AF occurred in 19 patients during a mean follow-up of 5.1 years. Plasma ANP and BNP were significantly higher in the patients who developed chronic AF after implantation than in those who did not, despite similar ANP and BNP levels between the 2 groups before implantation. Post-implant high BNP and a history of paroxysmal AF were independent predictors of chronic AF by a multivariate Cox proportional hazards analysis. Plasma BNP can predict the development of chronic AF after VVI pacemaker implantation in patients with SSS because increased levels may reflect latent hemodynamic abnormalities, which may contribute to the development of AF after VVI pacemaker implantation. |
| Databáze: | OpenAIRE |
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