A Multicenter, Open-Label Study of an Intravenous Short-Acting β1-Adrenergic Receptor Antagonist Landiolol Hydrochloride for Coronary Computed Tomography Angiography by 16-Slice Multi-Detector Computed Tomography in Japanese Patients with Suspected Ischemic Cardiac Disease
| Autor: | Takuhiro Yamaguchi, Misako Iino, Kazuhiro Hara, Akira Yamashina, Masaharu Hirano, Masahiro Jinzaki, Yuji Ikari, Mitsunobu Tanimoto, Sachio Kuribayashi |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Hydrochloride Morpholines Adrenergic beta-Antagonists Myocardial Ischemia Coronary Angiography β1 adrenergic receptor chemistry.chemical_compound Heart Rate Multidetector Computed Tomography Heart rate Humans Urea Medicine Original Research Article Aged Pharmacology medicine.diagnostic_test business.industry Coronary computed tomography angiography Antagonist Landiolol Middle Aged chemistry Injections Intravenous Angiography Female Nuclear medicine business medicine.drug |
| Zdroj: | Drugs in R&D |
| ISSN: | 1179-6901 1174-5886 |
| DOI: | 10.1007/s40268-014-0056-6 |
| Popis: | Background During coronary computed tomography (CT) angiography (CCTA), β-blockers (β-adrenergic receptor antagonists) have commonly been used to lower heart rate and improve image quality. Objectives The aim of this study was to investigate the image quality-improving effect as well as the heart rate-lowering effect of landiolol hydrochloride (an intravenous short-acting β1-adrenergic receptor antagonist) in CCTA by 16-slice multi-detector CT (MDCT). Methods A total of 39 subjects suspected of having ischemic cardiac disease and requiring CCTA received 0.125 mg/kg of landiolol hydrochloride to study the efficacy and safety of landiolol hydrochloride in a multicenter open-label clinical study. The endpoint was the diagnosable proportion (proportion of subjects whose coronary stenosis was diagnosable). Results The diagnosable proportions for the reconstruction images at mid-diastole were 56.0 %. The diagnosable proportions for the optimal reconstruction images were 65.4 %. The mean heart rate-lowering effect was observed soon after administration of landiolol hydrochloride; the peak of the effect was reached in 3–5 min, and the effect wore off in 30 min after completion of administration. The mean heart rate-lowering proportion at that time was −14.46 ± 8.4 %. Conclusions Landiolol hydrochloride was confirmed to reduce heart rate significantly and rapidly after intravenous injection and this suggests that the study drug is a safe and useful agent for improving the image quality of CCTA by 16-slice MDCT. |
| Databáze: | OpenAIRE |
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