Tetrahedral DNA nanostructures as drug delivery and bioimaging platforms in cancer therapy
| Autor: | Thaned Kangsamaksin, Anuttara Udomprasert, Ratchanee Duangrat |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Computer science medicine.medical_treatment Antineoplastic Agents Nanotechnology Review Article Targeted therapy Structure-Activity Relationship 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Dna nanostructures Neoplasms DNA nanotechnology medicine Animals Humans cancer Molecular Targeted Therapy Review Articles tetrahedron Drug Carriers nanotechnology Oligonucleotide DNA nanostructure DNA General Medicine targeted therapy Precision medicine Molecular Imaging Nanostructures Nanomedicine 030104 developmental biology Oncology Drug Design 030220 oncology & carcinogenesis Drug delivery Nanocarriers |
| Zdroj: | Cancer Science |
| ISSN: | 1349-7006 1347-9032 |
| Popis: | Structural DNA nanotechnology enables DNA to be used as nanomaterials for novel nanostructure construction with unprecedented functionalities. Artificial DNA nanostructures can be designed and generated with precisely controlled features, resulting in its utility in bionanotechnological and biomedical applications. A tetrahedral DNA nanostructure (TDN), the most popular DNA nanostructure, with high stability and simple synthesis procedure, is a promising candidate as nanocarriers in drug delivery and bioimaging platforms, particularly in precision medicine as well as diagnosis for cancer therapy. Recent evidence collectively indicated that TDN successfully enhanced cancer therapeutic efficiency both in vitro and in vivo. Here, we summarize the development of TDN and highlight various aspects of TDN applications in cancer therapy based on previous reports, including anticancer drug loading, photodynamic therapy, therapeutic oligonucleotides, bioimaging platforms, and other molecules and discuss a perspective in opportunities and challenges for future TDN‐based nanomedicine. This review summarizes the development of tetrahedral DNA nanostructure (TDN) and highlights various aspects of TDN applications in cancer therapy based on previous reports, including anticancer drug loading, photodynamic therapy, therapeutic oligonucleotides, and bioimaging platforms, and discuss a perspective in opportunities and challenges for future TDN‐based nanomedicine. |
| Databáze: | OpenAIRE |
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