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Sustained release (SR), sustained action (SA), extended release (ER, XR,OR XL), time release or timed release, controlled release (CR), modification release (MR), or continuous release (CR), is a mechanism used in pill tablets or capsules to dissolve slowly and release a drug over time. The advantages of sustained-release tablets or capsules are that they can often be taken less frequently then immediate-release formulation of the same drug, and that they keep steadier levels of the drug in the bloodstream. The present investigation was aimed to study sustained release tablets of diclofenac sodium using Ethyl cellulose, Magnesium state, Hydroxypropyl methyl cellulose by melt granulation method. Five different formulations F1, F2, F3, F4, and F5 were prepared and compressed to form tablets. These tablets were characterized for their physicochemical properties like hardness, thickness, weight variation, disintegration time, dissolution time etc. The Weight variation was found 0.11%, angle of repose was found to be 27.23 which indicated good flow also the drug release studies showed sustained release of drug upto 12 hrs. The main aim of preparing sustained release formulations was intended to modify and improve the drug performance by increasing the duration of drug action, decreasing the frequency of dosing, decreasing the required dose employed and providing uniform drug delivery KEYWORDS: Sustained release drug delivery systems, Diclofenac Sodium, Melt Granulation, Hardness and Dissolution time. |
