Very high relative seroprevalence of anti-SARS-CoV-2 antibodies among communities in Bangui, Central African Republic
| Autor: | Pr. Emmanuel Nakoune, Brice Martial Yambiyo, Alexandre Manirakiza, Joella Namsenei, Pr. Jean de Dieu Longo, Marie-Astrid Vernet, Jean Baptiste Roungou, Pr. Narcisse Patrice Komas, Modeste Bouhouda, Christian Malaka, Cathy Sandra Goimelle Coti-Reckoundji, Pr. Henri Saint-Calver Diemer, Guy Vernet, Pr. Gérard Grésenguet, Marie Roseline Darnycka Belizaire |
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| Rok vydání: | 2021 |
| Předmět: |
History
medicine.medical_specialty education.field_of_study Polymers and Plastics business.industry Public health Population Industrial and Manufacturing Engineering Herd immunity Medicine Seroprevalence Residence Cumulative incidence Business and International Management business education Serostatus Sex ratio Demography |
| DOI: | 10.1101/2021.11.18.21266496 |
| Popis: | BackgroundLarge-scale population-based seroprevalence studies of SARS-CoV-2 are essential to characterize the cumulative incidence of SARS-CoV-2 infection and to extrapolate the prevalence of presumptive immunity at the population level.ObjectiveThe objective of our survey was to estimate the cumulative population immunity for COVID-19 and to identify individual characteristics associated with a positive serostatus.MethodThis was a clustered cross-sectional study conducted from July 12 to August 20, 2021, in households in the city of Bangui, the capital of the Central African Republic. Information regarding demographic characteristics (age, gender, and place of residence), comorbidities (chronic diseases) was collected. A venous blood sample was obtained for each participant to determine the level of total anti-SARS-CoV-2 antibodies using a WANTAI SARS-CoV-2 Ab ELISA kit.ResultsAll up, 799 participants were surveyed. The average age was 27 years, and 45·8% of the respondents were male (sex ratio: 0.8). The overall proportion of respondents with a positive serostatus was 74·1%. Participants over 20 years of age were twice as likely to have a positive serostatus, with an OR of 2.· ·2 (95% CI: [1·6, 3·1]).InterpretationThe results of this survey revealed a high cumulative level of immunity in Bangui, thus indicating a significant degree of spread of SARS-CoV-2 in the population. The public health implications of this high level of immunity to SARS-CoV-2, particularly on its variants burden, remain to be determined.FundingThis study was funded by the French Ministry for Europe and Foreign Affairs through the REPAIR COVID-19-Africa project coordinated by the Pasteur International Network association. |
| Databáze: | OpenAIRE |
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