Protective Effect of L-2-Oxothiazolidine-4-Carboxylate Treatment of Cyclophosphamide-Induced Cystitis in Rats
| Autor: | C. Leaf, Joseph A. Safron, D. Rice, Donovan Gordon, Randy D. White |
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| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Journal of Urology. 157:1946-1950 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(01)64907-3 |
| Popis: | Purpose: Hemorrhagic cystitis is a therapy-limiting side effect of cyclophosphamide (CP) treatment for cancer. The purpose of this study was to investigate the potential protective effect of L-2-oxothiazolidine-4-carboxylate (OTZ; Procysteine [R]) on CP-induced cystitis in the rat.Materials and Methods: Thirty-six rats were divided into 6 groups: Group 1-Untreated controls, Group 2-OTZ alone (100 mg./kg., p.o.), Group 3-CP alone (68 mg./kg., i.v.), Group 4-CP + OTZ (68 mg./kg., i.v. + 100 mg./kg., p.o.), Group 5-CP + OTZ (68 mg./kg., i.v. + 1.0 g./kg., i.v.), and Group 6-CP + OTZ (68 mg./kg., i.v. + 1.0 gm./kg., i.p.). OTZ was given a day to groups 2 and 4 on the day prior to and on the day of CP administration. OTZ was given twice a day to groups 5 and 6 on the day prior to, the day of, and the day after CP administration. On the day of CP administration, CP was given 30 minutes prior to OTZ. Blood and bladder samples were taken for evaluation two days after CP administration.Results: Expected de... |
| Databáze: | OpenAIRE |
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