Antidepressant effects on kinase gene expression patterns in rat brain
| Autor: | Vadivel Ganapathy, H.M. Hobby, C.F. Gillespie, You-Jun Fei, T. Stoming, F. H. Leibach, Jeffrey L. Rausch |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Serotonin uptake Serotonin reuptake inhibitor Citalopram Pharmacology Fluoxetine Ca2+/calmodulin-dependent protein kinase Internal medicine medicine Animals RNA Messenger Protein kinase A Protein kinase C Serotonin transporter Oligonucleotide Array Sequence Analysis biology Kinase General Neuroscience Phosphotransferases Brain Rats Endocrinology Gene Expression Regulation biology.protein Antidepressive Agents Second-Generation medicine.drug |
| Zdroj: | Neuroscience Letters. 334:91-94 |
| ISSN: | 0304-3940 |
| Popis: | Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression. |
| Databáze: | OpenAIRE |
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