A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation

Autor: Diego Lozano-Soldevilla, Juan A. Barcia, Vanesa Soto-León, Antonio Oliviero, Blanca Reneses-Prieto, Svenja Treu, Fernando Lopez-Sosa, Javier J. Gonzalez-Rosa, Bryan A. Strange
Přispěvatelé: [Treu,S, Gonzalez-Rosa,JJ, Lozano-Soldevilla,D, Lopez-Sosa,F, Strange,BA] Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain. [Gonzalez-Rosa,JJ, Lopez-Sosa,F] University of Cadiz, Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain. [Soto-Leon,V, Oliviero,A] Hospital Nacional de Parapléjicos, FENNSI Group, Hospital Nacional de Parapléjicos, Toledo, Spain. [Reneses-Prieto,B] Department of Psychiatry, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria San Carlos, Universidad Complutense de Madrid, Spain. [Barcia,JA] Department of Neurosurgery, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria San Carlos, Universidad Complutense de Madrid, Spain., This work was supported by Project grants SAF2015-65982-R from the Spanish Ministry of Economy and Competitiveness to BS and PSI2014-58654-JIN to JGR, an FPI Predoctoral Fellowship (BES2016-079470) to ST, and BIAL Foundation Grant 119/12 to BS. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC-2018-COG 819814)., Psicología
Rok vydání: 2020
Předmět:
Obsessive-Compulsive Disorder
medicine.medical_treatment
Deep Brain Stimulation
Nucleus Accumbens
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Coupling
0302 clinical medicine
Obsessive-compulsive disorder
Deep brain stimulation
EEG
media_common
General Neuroscience
European research
05 social sciences
Núcleo accumbens
Frontal Lobe
Corteza prefrontal
Estimulación encefálica profunda
Nucleus accumbens
Christian ministry
Psychology
RC321-571
Ventromedial frontal cross-frequency coupling
Electroencefalografía
Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Frontal Lobe [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Electric Stimulation Therapy::Deep Brain Stimulation [Medical Subject Headings]
Phenomena and Processes::Physiological Phenomena::Electrophysiological Phenomena [Medical Subject Headings]
medicine.medical_specialty
Biophysics
Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Basal Ganglia::Nucleus Accumbens [Medical Subject Headings]
Neurosciences. Biological psychiatry. Neuropsychiatry
behavioral disciplines and activities
050105 experimental psychology
03 medical and health sciences
Obsessive compulsive
medicine
Psychiatry and Psychology::Mental Disorders::Anxiety Disorders::Obsessive-Compulsive Disorder [Medical Subject Headings]
media_common.cataloged_instance
Humans
0501 psychology and cognitive sciences
European union
Psychiatry
Trastorno obsesivo compulsivo
Electrophysiological Phenomena
Neurology (clinical)
Ventromedial frontal cross-frequency
030217 neurology & neurosurgery
Acoplamiento neurovascular
Zdroj: Brain Stimulation Volume 14, Issue 4, July–August 2021, Pages 761-770
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
Brain Stimulation, Vol 14, Iss 4, Pp 761-770 (2021)
ISSN: 1876-4754
Popis: Background: Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized. Objective/hypothesis: The primary goal of this study was to investigate the neuronal synchronization in OCD patients. We predicted aberrant oscillatory activity in frontal regions compared to healthy control subjects, which would be alleviated by deep brain stimulation (DBS) of the nucleus accumbens (NAc). Methods: We compared scalp EEG recordings from nine patients with OCD treated with NAc-DBS with recordings from healthy controls, matched for age and gender. Within the patient group, EEG activity was compared with DBS turned off vs. stimulation at typical clinical settings (3.5 V, frequency of stimulation 130 Hz, pulse width 60 ms). In addition, intracranial EEG was recorded directly from depth macro electrodes in the NAc in four OCD patients. Results: Cross-frequency coupling between the phase of alpha/low beta oscillations and amplitude of high gamma was significantly increased over midline frontal and parietal electrodes in patients when stimulation was turned off, compared to controls. Critically, in patients, beta (16-25 Hz)-gamma (110-166 Hz) phase amplitude coupling source localized to the ventromedial prefrontal cortex, and was reduced when NAc-DBS was active. In contrast, intracranial EEG recordings showed no beta-gamma phase amplitude coupling. The contribution of non-sinusoidal beta waveforms to this coupling are reported. Conclusion: We reveal an increased beta-gamma phase amplitude coupling in fronto-central scalp sensors in patients suffering from OCD, compared to healthy controls, which may derive from ventromedial prefrontal regions implicated in OCD and is normalized by DBS of the nucleus accumbens. This aberrant cross-frequency coupling could represent a biomarker of OCD, as well as a target for novel therapeutic approaches. (C) 2021 The Authors. Published by Elsevier Inc.
This work was supported by Project grants SAF2015-65982-R from the Spanish Ministry of Economy and Competitiveness to BS and PSI2014-58654-JIN to JGR, an FPI Predoctoral Fellowship (BES-2016-079470) to ST, and BIAL Foundation Grant 119/12 to BS. This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (ERC-2018-COG 819814).
Databáze: OpenAIRE
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