The pharmacological protection of renal function in patients undergoing cardiac surgery
| Autor: | Betul Ogutmen, İlhan Öztekin, Emine Bilge Narin, SeherDeniz Oztekin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
cystatin-c
medicine.medical_specialty Dopamine Renal function law.invention chemistry.chemical_compound law urine microalbumin/creatinine ratio medicine Cardiopulmonary bypass Adverse effect Creatinine biology business.industry mannitol Furosemide General Medicine Coronary artery surgery Cardiac surgery microalbumin Cystatin C chemistry Anesthesia biology.protein Original Article Mannitol business medicine.drug |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X 1682-024X |
| Popis: | Objectives: To compare the effects of different routes and timings of administration of dopamine and mannitol used to alleviate the adverse effects of prolonged cardiopulmonary bypass (CPB) on renal functions in coronary artery surgery. Methods: Group I (n: 25 patients): Mannitol 1 g/kg was added into the priming solution for CPB. Group II (n: 25 patients): IV dopamine was administered at a dose of 2 μg/kg/min during the time period between anesthesia induction and end of surgery. Group III (n: 25 patients): IV dopamine was administered at a dose of 2 μg/kg/min during the time period between anesthesia induction and end of surgery and mannitol 1 g/kg was added into the priming solution for CPB. Group IV (n: 25 patients) (Controls): Furosemide was given when the urine output was low. Results: There was a significant increase in post operative urine microalbumin/creatinine ratio in all groups (p < 0.05), even increase of cystatin-c in Groups I, II and III (p < 0.01). Conclusions: We believe that concurrent use of dopamine infusion (2 μg/kg/min) with mannitol (1 g/kg) during CPB may represent a more effective strategy for the prevention of the untoward effects of CPB on renal functions. |
| Databáze: | OpenAIRE |
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