Fate of emepronium in man in relation to its pharmacological effects
| Autor: | A. Sundwall, B. Strindberg, J. Vessman |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Saliva Time Factors Administration Oral Urine Injections Intramuscular Intestinal absorption Feces Oral administration Heart Rate Internal medicine medicine Benzene Derivatives Humans Pharmacology (medical) Carbon Radioisotopes Vision Ocular Pharmacology Chemistry Feces analysis Parasympatholytics General Medicine Quaternary Ammonium Compounds Endocrinology Intestinal Absorption Salivation Drug metabolism Emepronium |
| Zdroj: | European journal of clinical pharmacology. 6(3) |
| ISSN: | 0031-6970 |
| Popis: | After oral administration of14C-labelled emepronium (150 mg) to two subjects, 1.8 and 3.9% of the radioactivity were recovered from the urine within 24 h, of which 50 and 56% respectively, were excreted during the first 6 h. 23 to 35% of the radioactivity in the urine consisted of emepronium metabolites. 25 mg of the cold compound was injected i.m. in 4 subjects; about 31% was excreted in the urine and about 45% in the faeces within 3 days, probably indicating extensive biliary excretion of unaltered drug. The half-life of emepronium in serum ranged from 1.5 to 2.25 h. The near point of accommodation, salivation and heart rate were compared with the serum concentration of emepronium in a randomized cross-over study in 4 subjects. The heart rate was increased significantly at serum concentrations of about 450 ng/ml, and the secretion of saliva was markedly decreased at about 250 ng/ml. The near point was affected only at the highest serum concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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