N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model
| Autor: | Emilie Brun, Aurore Marie, Gaëlle Naert, Sergio Gonzalez-Gonzalez, Johann Meunier, Elodie Flaszka, Veronique Baudoux, Sylvie Cosnier-Pucheu, Francois Joseph Roman, Susanna Malmström |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Senescence medicine.medical_specialty antioxidant Hearing loss Inflammation medicine.disease_cause Orginal Article Pathology and Forensic Medicine Acetylcysteine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine otorhinolaryngologic diseases Memory impairment hearing loss SAMP8 business.industry aging Cell Biology N-acetylcysteine 030104 developmental biology Auditory brainstem response Endocrinology Apoptosis Neurology (clinical) Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Aging and Disease |
| ISSN: | 2152-5250 |
| Popis: | Age-related hearing loss (ARHL) is the most common sensory disorder in the elderly population. SAMP8 mouse model presents accelerated senescence and has been identified as a model of gerontological research. SAMP8 displays a progressive age-related decline in brain function associated with a progressive hearing loss mimicking human aging memory deficits and ARHL. The molecular mechanisms associated with SAMP8 senescence process involve oxidative stress leading to chronic inflammation and apoptosis. Here, we studied the effect of N-acetylcysteine (NAC), an antioxidant, on SAMP8 hearing loss and memory to determine the potential interest of this model in the study of new antioxidant therapies. We observed a strong decrease of auditory brainstem response thresholds from 45 to 75 days of age and an increase of distortion product amplitudes from 60 to 75 days in NAC treated group compared to vehicle. Moreover, NAC treated group presented also an increase of memory performance at 60 and 105 days of age. These results confirm that NAC delays the senescence process by slowing the age-related hearing loss, protecting the cochlear hair cells and improving memory, suggesting that antioxidants could be a pharmacological target for age-related hearing and memory loss. |
| Databáze: | OpenAIRE |
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