Epidemiological characterization and prognostic factors in patients with confirmed cerebral cryptococcosis in central Taiwan
| Autor: | Yu-Min Chen, Shao-Hung Wang, Hiu-Ngar Sy, Yu-Jun Chang, Hua-Cheg Yen, Wei-Liang Chen, Chang-Hua Chen, Li-Jhen Lin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Pharmacology toxicology Cryptococcus gattii Cryptococcosis Toxicology Risk Assessment lcsh:RA1190-1270 Internal medicine Epidemiology lcsh:Zoology Medicine In patient Meningitis lcsh:QL1-991 Outcome lcsh:Toxicology. Poisons Cryptococcus neoformans biology business.industry Research Cerebral cryptococcosis biology.organism_classification medicine.disease Infectious Diseases Immunology Animal Science and Zoology Parasitology business Cryptococcal meningitis |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 21, Iss 0 (2015) The Journal of Venomous Animals and Toxins Including Tropical Diseases Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 21, Article number: 12, Published: 11 AUG 2015 |
| ISSN: | 1678-9199 |
| Popis: | BackgroundCryptococcal meningitis is a deadly fungal infection. This study aimed to characterize the epidemiology of cerebral cryptococcosis and to define its prognostic factors.MethodsThis cross-sectional study collected clinical information from cryptococcal meningitis patients with confirmed cerebral cryptococcosis from 2006 to 2012 at the Changhua Christian Healthcare System to access prognostic factors.ResultsFifty-nine adult cryptococcal meningitis patients were studied. The incidence at Changhua Christian Healthcare System was approximately 170 episodes per 100,000 patients within the studied period. Forty-one of 59 cryptococcal meningitis patients developed complications. Overall, 12 of 59 patients died, for a three-month mortality rate of 20.3 %. Prognostic factors positively associated with the three-month mortality included age (>55 years), patient delay, prolonged delay by the doctor in administering antifungal agent therapy, duration of intensive care unit stay, chronic lung disease, cryptococcemia, headache, altered mental status, positive blood cultures, and high cerebrospinal fluid opening pressure (>250 mm H2O).ConclusionsWe strongly recommend early administration of an antifungal agent to each suspected cryptococcal meningitis patient to decrease both the delay by doctors in administering therapy and the mortality risk. Aggressive and supportive care for severe cryptococcal meningitis patients is critical to decrease overall mortality from this infection. |
| Databáze: | OpenAIRE |
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