Fatal Enteritis Necroticans (Pigbel) in a Diabetic Adult
| Autor: | Charu Subramony, Michael D Hughson, Jonathan D. Fratkin, Lizhen Gui |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
DNA
Bacterial Abdominal pain Pathology medicine.medical_specialty Clostridium perfringens Peritonitis Ileum medicine.disease_cause Polymerase Chain Reaction Pathology and Forensic Medicine Enteritis Jejunum Fatal Outcome medicine Humans Aged business.industry digestive oral and skin physiology Type 2 Diabetes Mellitus medicine.disease medicine.anatomical_structure Diabetes Mellitus Type 2 Clostridium Infections Female Bloody diarrhea medicine.symptom business |
| Zdroj: | Modern Pathology. 15:66-70 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.3880491 |
| Popis: | Enteritis necroticans is a segmental necrotizing infection of the jejunum and ileum caused by Clostridium perfringens, Type C. The disease occurs sporadically in parts of Asia, Africa, and the South Pacific, where it primarily affects children with severe protein malnutrition. The disease is extremely rare in developed countries, where it has been seen primarily in diabetics. Two cases have previously been reported in the United States, one in a child with poorly controlled Type 1 diabetes. A 66-year-old woman with a 12-year history of Type 2 diabetes mellitus developed severe abdominal pain and bloody diarrhea after eating a meal of turkey sausage. She died unattended at home. An autopsy showed peritonitis and segmental necrosis of the jejunum and ileum. Microscopic examination showed Gram-positive club-shaped bacilli consistent with Clostridia coating a necrotic mucosa. Products of cpa and cpb genes of C. perfringens, Type C were identified in the necrotic jejunum by polymerase chain reaction amplification. |
| Databáze: | OpenAIRE |
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