Disordered arrangements of basal cells as a prognostic factor for oral epithelial dysplasia: a morphometric study of 96 cases
| Autor: | Takeshi Okamura, Kei Sakamoto, Kiyoshi Harada, Taisuke Mori, Toshiyuki Izumo, Hisao Yagishita |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Epithelial dysplasia Pathology medicine.medical_specialty Biopsy Basement Membrane Pathology and Forensic Medicine 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Predictive Value of Tests Tongue medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Aged Aged 80 and over Basement membrane medicine.diagnostic_test business.industry Mouth Mucosa Epithelial Cells Middle Aged Apical membrane Prognosis medicine.disease Tongue Neoplasms 030104 developmental biology medicine.anatomical_structure Carcinoma Basal Cell 030220 oncology & carcinogenesis Predictive value of tests Female Surgery Oral Surgery business Precancerous Conditions |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 122:355-361 |
| ISSN: | 2212-4403 |
| Popis: | Objective The aim of this study was to assess objectively the predictive value of the atypical appearance of the basal layer of oral epithelial dysplasia (OED) for development into invasive carcinoma. Study Design Ninety-six OED cases were examined. These cases were divided into 2 groups: 38 cases that developed into invasive carcinoma and 58 cases that did not. Furthermore, 12 histopathological factors were quantified morphometrically in each case and assessed by Cox's proportional hazards model. Results The standard deviation of the length between the apical membrane of the basal cells and the basement membrane was significantly associated with development of OED into invasive carcinoma (P Conclusion We provided novel, objective data demonstrating that an atypical appearance, especially the disordered arrangement of the basal cells representing loss of polarity, may be useful for predicting the development of OED into invasive carcinoma of the tongue. |
| Databáze: | OpenAIRE |
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