Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016
Autor: | Beate Ritz, Julia E. Heck, Ondine S. von Ehrenstein, Di He, Jørn Olsen, Johnni Hansen, Clinton Hall |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Cancer Research Yolk sac tumor Denmark Social contact 0302 clinical medicine Pregnancy Paternal Exposure/adverse effects 030212 general & internal medicine Registries Child Maternal Exposure/adverse effects education.field_of_study Obstetrics Teratoma Neoplasms Germ Cell and Embryonal medicine.anatomical_structure Oncology Maternal Exposure 030220 oncology & carcinogenesis Solvents/toxicity Child Preschool Paternal Exposure Female Childhood cancer medicine.medical_specialty Adolescent Offspring Population Occupations/statistics & numerical data 03 medical and health sciences Occupational Exposure medicine Humans Industry Yolk sac Occupations education Original Paper Industry/statistics & numerical data business.industry Occupational Exposure/adverse effects Case-control study Infant Newborn Infant Odds ratio medicine.disease Neoplasms Germ Cell and Embryonal/epidemiology Denmark/epidemiology Case-Control Studies Carcinogens Solvents Job exposure matrix Germ cell tumors business Carcinogens/toxicity |
Zdroj: | Cancer Causes & Control Hall, C, Hansen, J, Olsen, J, He, D, von Ehrenstein, O S, Ritz, B & Heck, J E 2021, ' Parental occupation and childhood germ cell tumors : a case–control study in Denmark, 1968–2016 ', Cancer Causes and Control, vol. 32, no. 8, pp. 827-836 . https://doi.org/10.1007/s10552-021-01434-0 |
ISSN: | 1573-7225 0957-5243 |
Popis: | Purpose To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 ( Results Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). Conclusion Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors. |
Databáze: | OpenAIRE |
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