Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016

Autor: Beate Ritz, Julia E. Heck, Ondine S. von Ehrenstein, Di He, Jørn Olsen, Johnni Hansen, Clinton Hall
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Cancer Research
Yolk sac tumor
Denmark
Social contact
0302 clinical medicine
Pregnancy
Paternal Exposure/adverse effects
030212 general & internal medicine
Registries
Child
Maternal Exposure/adverse effects
education.field_of_study
Obstetrics
Teratoma
Neoplasms
Germ Cell and Embryonal
medicine.anatomical_structure
Oncology
Maternal Exposure
030220 oncology & carcinogenesis
Solvents/toxicity
Child
Preschool
Paternal Exposure
Female
Childhood cancer
medicine.medical_specialty
Adolescent
Offspring
Population
Occupations/statistics & numerical data
03 medical and health sciences
Occupational Exposure
medicine
Humans
Industry
Yolk sac
Occupations
education
Original Paper
Industry/statistics & numerical data
business.industry
Occupational Exposure/adverse effects
Case-control study
Infant
Newborn
Infant
Odds ratio
medicine.disease
Neoplasms
Germ Cell and Embryonal/epidemiology
Denmark/epidemiology
Case-Control Studies
Carcinogens
Solvents
Job exposure matrix
Germ cell tumors
business
Carcinogens/toxicity
Zdroj: Cancer Causes & Control
Hall, C, Hansen, J, Olsen, J, He, D, von Ehrenstein, O S, Ritz, B & Heck, J E 2021, ' Parental occupation and childhood germ cell tumors : a case–control study in Denmark, 1968–2016 ', Cancer Causes and Control, vol. 32, no. 8, pp. 827-836 . https://doi.org/10.1007/s10552-021-01434-0
ISSN: 1573-7225
0957-5243
Popis: Purpose To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 ( Results Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). Conclusion Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.
Databáze: OpenAIRE
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