Genetic Ablation of V2a Ipsilateral Interneurons Disrupts Left-Right Locomotor Coordination in Mammalian Spinal Cord
| Autor: | Line Lundfald, Toshiaki Endo, Steven A. Crone, Thomas M. Jessell, Laskaro Zagoraiou, Katharina A. Quinlan, Kamal Sharma, Carlos Ernesto Restrepo, Ole Kiehn, Steven Droho, Jennifer Setlak |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Neural substrate Commissural Interneurons Neuroscience(all) DEVBIO Mice Transgenic Biology Motor Activity MOLNEURO Functional Laterality 03 medical and health sciences Mice 0302 clinical medicine Interneurons medicine Biological neural network Alternation (formal language theory) Animals Genetic ablation 030304 developmental biology Homeodomain Proteins Recombination Genetic 0303 health sciences Afferent Pathways General Neuroscience musculoskeletal neural and ocular physiology Commissure Spinal cord Electric Stimulation Mice Inbred C57BL medicine.anatomical_structure nervous system Spinal Cord Excitatory postsynaptic potential CELLBIO Female Neuroscience 030217 neurology & neurosurgery Gene Deletion Psychomotor Performance Transcription Factors |
| Zdroj: | Neuron. 60(1):70-83 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2008.08.009 |
| Popis: | Summary The initiation and coordination of activity in limb muscles are the main functions of neural circuits that control locomotion. Commissural neurons connect locomotor circuits on the two sides of the spinal cord, and represent the known neural substrate for left-right coordination. Here we demonstrate that a group of ipsilateral interneurons, V2a interneurons, plays an essential role in the control of left-right alternation. In the absence of V2a interneurons, the spinal cord fails to exhibit consistent left–right alternation. Locomotor burst activity shows increased variability, but flexor-extensor coordination is unaffected. Anatomical tracing studies reveal a direct excitatory input of V2a interneurons onto commissural interneurons, including a set of molecularly defined V0 neurons that drive left-right alternation. Our findings imply that the neural substrate for left-right coordination consists of at least two components; commissural neurons and a class of ipsilateral interneurons that activate commissural pathways. |
| Databáze: | OpenAIRE |
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